An investigation into the potential impact of using a different Dissertation

An investigation into the potential impact of using a different approach of people management and its possible benefits in impro - Dissertation Example ually helps to improve the overall organizational performance has been argued a lot. Organization around the world has now understood that employees are the biggest asset. Likewise the attitude and performance of the employees can act as a decisive factor for the success and failure of a venture. Various studies often shed light on the fact that management of people or people management is the most difficult task for an organization (Bach, 2005). The term people management can be simply referred to as the management of human resources of an organization. It encompasses various tasks such as hiring, training and management, providing support to the employees and also controlling the workforce. Moreover the specified tasks are hiring, administration, communication, organization development, compensation, safety, wellness, benefits, performance management, employee motivation and training. In this context according to some eminent scholars, the key requirements towards the success of an organization are highly dependent on the commitment levels, management dedications as well as the performance of the employees of the organization. 1.1 Introduction to the Study The study will entail various performance management tools and will also highlight different techniques of people management. Furthermore the report will give insights to the topics pertaining to people management in an organization. It will be segmented into five sections. The first section will define the important concepts and will offer a brief overview of the company. Furthermore the research objective along with the research questions will be also presented. The second section of the project will be the literature review of the area of study. In this context, the study will describe earlier works of the scholars in the field of people management. In addition books and scholarly articles will be also consulted. The sources that will be used to accomplish the study include electronic sources, books, and journal articles. The third segment will portray the research methodology. The methodology to be followed for a conducting the study will be illuminated. In this context of the study, both primary as well as secondary data will be collected. The instruments to be used for collecting the primary data are questionnaire and focus group interviews. The questionnaire survey is meant for the employees of BeechWood, while the focus group interview is meant for the HR executives and managers of Beechwood Company. The fourth section will be about analyzing the data. The recorded data will be analyzed and meaningful information will be provided. Both qualitative as well as

Monitoring the glucose level as well as alteration in expression of Research Proposal

Monitoring the glucose level as well as alteration in expression of m-RNA and protien levels of glucose transporters(GLUT4) in d - Research Proposal Example The reduction of insulin activity removes the glucose transporter in the urine samples out of the body. This concludes that glucose level monitoring and the Vitamin D level monitoring is very important for the type 2 Diabetes patients.1 When the Vitamin D binds to the vitamin D receptor (VDR), a heterodimer is formed. This hetereodimer then binds to the DNA and initiates many cofactors leading to the increase in the transcription of the genes that are responsible for the production of the proteins that control the calcium homeostasis. Vitamin D regulates the insulin receptor gene expression at the genetic level. The mRNA that codes for insulin receptor gene is produced at large numbers by increasing the expression level. The increase in the insulin receptor will increase the binding of the insulin and makes the GLUT4 transporter gene translocation from the intracellular level to the plasma membrane. 2 This increase in flux increases the glucose metabolism and thus controls the type 2 Diabetes mellitus in humans.GLUT 4 contain the phosphate at the basal state. The phosphorylation of GLUT4 is mediated by the cyclic cAMP- dependent protein kinase inhibiting the glucose transport.2 Scientific Background: A study was carried out in the year 1993, to identify the genes that are responsible for the regulatory domain of the GLUT4 in the adipose tissue. The transcriptional regulation of the gene was studied in the murine C2C12 skeletal muscle cell line. Transient transfection of the 5’ and 3’ deletions of the GLUT4 5’ flanking DNA has identified a region of 281 base pairs present at the myotube-specific expression. 3 The total RNA was isolated and used for Northern Blot analysis and hybridization was carried out. This gene was then inserted into the luciferase EcoRI- DraI fragment plasmid and further analysis was carried out. 3 The GLUT4 mRNA was found to be dependent on the thyroid hormone. This region was also found between the -517 and -237 regio n. This 281 base pair region is found to play a major role in understanding the mechanism that controls the GLUT4 gene expression in the skeletal muscle. All these experiments were carried out in the rat model.3 The vitamin D deficiency is found to be associated with the impaired insulin secretion. When Vitamin D is supplied at sufficient level then it binds to the vitamin D receptors (VDRs) present in the pancreatic beta cells. VRD gene is present in the Chromosome 12-cen-q12. When allelic variations are done in the VDR receptor gene then glucose absorbance rate also varies. The genomic DNA was extracted from the four healthy individuals and the four SNPS at the intron 8 and Exon 9 was examined with the controls. 4 The peripheral blood samples were analyzed for the given SNPS at the VDR gene using the polymerase chain reaction and then by the restriction fragment length polymorphism (RFLP). The restriction sites looked for were TaqI, ApaI, BsmI and Tru91SNP. 4 It was found that the genotypes were similar in both the patients and control. This concluded that VDR is not the major gene for the Type 2 Diabetes mellitus. Hence further research is necessary for finding the responsible gene for Type 3 Diabetes mellitus.4 The vitamin D is not only the factor that is responsible for the insulin resistance. There are other factors too. The 25- hydroxyl vitamin D (25(OH)-D) is found to be inversely proportional to the insulin resistance and the (25( OH)-D) concentration is determined in the serum for the analysis. The association between the